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Rad50 Polyclonal Antibody

CAT: 0749-ABP52307-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP52307-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RAD50 double strand break repair protein encoded by RAD50 is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. RAD50 double strand break repair protein forms a complex with MRE11 and NBS1. RAD50 double strand break repair protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. RAD50 double strand break repair protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest RAD50 is essential for cell growth and viability. Mutations in RAD50 are the cause of Nijmegen breakage syndrome-like disorder.
Description
Rabbit Anti-Rad50 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
RAD50; DNA repair protein RAD50; hRAD50
Gene ID
10111
Accession Number
Q92878
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human Rad50 at AA range: 650-730
Clonality
Polyclonal
Tag
DNA repair protein RAD50
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
153kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Rad50 Polyclonal Antibody detects endogenous levels of Rad50 protein.
Observed Molecular Weight
153
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
RAD50; DNA repair protein RAD50; hRAD50
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q92878
Isotype
Rabbit IgG

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