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PKR Polyclonal Antibody

CAT: 0749-ABP52231-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP52231-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Eukaryotic translation initiation factor 2 alpha kinase 2 encoded by EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of eukaryotic translation initiation factor 2 alpha kinase 2 can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. Eukaryotic translation initiation factor 2 alpha kinase 2 encoded by EIF2AK2 is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for EIF2AK2.
Description
Rabbit Anti-PKR Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
Gene ID
5610
Accession Number
P19525
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human PKR around the non-phosphorylation site of T446
Clonality
Polyclonal
Tag
Interferon-induced double-stranded RNA-activated protein kinase
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
74kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
PKR Polyclonal Antibody detects endogenous levels of PKR protein.
Observed Molecular Weight
74
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P19525
Isotype
Rabbit IgG

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