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MRP-S12 Polyclonal Antibody

CAT: 0749-ABP51847-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51847-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
28S ribosomal protein S12 mitochondrial (mitochondrial ribosomal protein S12) is encoded by nuclear genes MRPS12 and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4) . Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
Description
Rabbit Anti-MRP-S12 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
MRPS12; RPMS12; RPSM12; 28S ribosomal protein S12; mitochondrial; MRP-S12; S12mt; MT-RPS12
Gene ID
6183
Accession Number
O15235
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human MRP-S12 at AA range: 40-120
Clonality
Polyclonal
Tag
28S ribosomal protein S12 mitochondrial
Applications
WB, IHC
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
20kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MRP-S12 Polyclonal Antibody detects endogenous levels of MRP-S12 protein.
Observed Molecular Weight
20
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300
Other Product Names
MRPS12; RPMS12; RPSM12; 28S ribosomal protein S12; mitochondrial; MRP-S12; S12mt; MT-RPS12
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O15235
Isotype
Rabbit IgG

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