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MMP-1 Polyclonal Antibody

CAT: 0749-ABP51803-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51803-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MMP1 encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs) . Interstitial collagenase in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. MMP1 is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD) . Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Description
Rabbit Anti-MMP-1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1
Gene ID
4312
Accession Number
P03956
Reactivity
Human, Rat
Immunogen
Synthesized peptide derived from the C-terminal region of human MMP-1 at AA range: 380-460
Clonality
Polyclonal
Tag
Interstitial collagenase
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
54kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MMP-1 Polyclonal Antibody detects endogenous levels of MMP-1 protein.
Observed Molecular Weight
54
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Other Product Names
MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P03956
Isotype
Rabbit IgG

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