MMP-1 Polyclonal Antibody

• Background:

  MMP1 encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs) . Interstitial collagenase in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. MMP1 is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD) . Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

• Description:

  Rabbit Anti-MMP-1 Polyclonal Antibody

• Product Name Alternative:

  MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1

• Gene ID:

  4312

• Accession Number:

  P03956

• Reactivity:

  Human, Rat

• Immunogen:

  Synthesized peptide derived from the C-terminal region of human MMP-1 at AA range: 380-460

• Clonality:

  Polyclonal

• Tag:

  Interstitial collagenase

• Applications:

  WB, IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  54kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  MMP-1 Polyclonal Antibody detects endogenous levels of MMP-1 protein.

• Observed Molecular Weight:

  54

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.

• Other Product Names:

  MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P03956

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG