MKP-1/2 Polyclonal Antibody

CAT: 0749-ABP51797-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP51797-01Size:30 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Dual specificity protein phosphatase 4 encoded by DUSP14 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
Description
Rabbit Anti-MKP-1/2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
DUSP1; CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100; DUSP4
Gene ID
1843/1846
Accession Number
P28562/Q13115
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human MKP-1/2 around the non-phosphorylation site of S296/318
Clonality
Polyclonal
Tag
Dual specificity protein phosphatase 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
41kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MKP-1/2 Polyclonal Antibody detects endogenous levels of MKP-1/2 protein.
Observed Molecular Weight
41
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
DUSP1; CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100; DUSP4
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P28562
Isotype
Rabbit IgG

Related Products

CatalogName
ABP54031-01MKP-2 Polyclonal Antibody
ABP51796-01MKP-1 Polyclonal Antibody
ABP50499-01MKP-1/2 (phospho Ser296/318) Polyclonal Antibody
ABP54030-01MKP-1 (phospho Ser359) Polyclonal Antibody
ABP54032-01MKP-3 Polyclonal Antibody
ABP54034-01MKP-4 Polyclonal Antibody
ABP53622-01MKP-5 Polyclonal Antibody
ABP56625-01MKP-7 Polyclonal Antibody
ABP53225-01EF-1 α1/2 Polyclonal Antibody
ABP52443-01Siah-1/2 Polyclonal Antibody

Alternative Products

CatalogName
MBS2539564-01MKP-1/2 Polyclonal Antibody
MBS9449928-01MKP-1/2 Polyclonal Conjugated Antibody
BS3768-01MKP-1/2 (Q290) polyclonal antibody
MBS8523754-01MKP-2 Polyclonal Antibody
41147-01MKP/2 Polyclonal Antibody
APRab13932-01MKP-1/2 Rabbit Polyclonal Antibody
abx011651MKP-1 / 2 Antibody
ABF6243MKP-1/2 Antibody

Popular Products