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KIR6.2 Polyclonal Antibody

CAT: 0749-ABP51677-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51677-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. ATP-sensitive inward rectifier potassium channel 11 encoded by KCNJ11 is an integral membrane protein and inward-rectifier type potassium channel. ATP-sensitive inward rectifier potassium channel 11, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM) . Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Description
Rabbit Anti-KIR6.2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K (+) channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11
Gene ID
3767
Accession Number
Q14654
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human KIR6.2 around the non-phosphorylation site of T224
Clonality
Polyclonal
Tag
ATP-sensitive inward rectifier potassium channel 11
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
40kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
KIR6.2 Polyclonal Antibody detects endogenous levels of KIR6.2 protein.
Observed Molecular Weight
40
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Other Product Names
KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K (+) channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q14654
Isotype
Rabbit IgG

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