GIT2 Polyclonal Antibody

CAT: 0749-ABP51428-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP51428-01Size:30 µL
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Background
GIT2 encodes a member of the GIT protein family, ARF GTPase-activating protein GIT2, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. GIT2 has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. GIT2 undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Description
Rabbit Anti-GIT2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
GIT2; KIAA0148; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2
Gene ID
9815
Accession Number
Q14161
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human GIT2 at AA range: 330-410
Clonality
Polyclonal
Tag
ARF GTPase-activating protein GIT2
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
84kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
GIT2 Polyclonal Antibody detects endogenous levels of GIT2 protein.
Observed Molecular Weight
84
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:10000; IF 1:50-200
Other Product Names
GIT2; KIAA0148; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q14161
Isotype
Rabbit IgG

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