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Merbromin

CAT: 0804-HY-B0961-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0961-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC50 of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye[1][2].
CAS Number
[129-16-8]
Product Name Alternative
Mercury dibromofluorescein (disodium salt) ; ZP1
UNSPSC
12171500
Hazard Statement
H300, H310, H330, H373, H400, H410
Target
Flavivirus; Proteasome
Type
Dye Reagents
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Merbromin.html
Solubility
DMSO : 6.67 mg/mL (ultrasonic)
Smiles
O[Hg]C1=C(O[Na])C(Br)=CC(C2C3=C(C=CC=C3)C(O[Na])=O)=C1OC4=C2C=C(Br)C(O)=C4
Molecular Formula
C20H10Br2HgNa2O6
Molecular Weight
752.67
Precautions
H300, H310, H330, H373, H400, H410
References & Citations
[1]Xiangling Cui , et al. Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313.|[2]Junjie Chen, et al. Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2. Biochem Biophys Res Commun. 2022 Feb 5:591:118-123.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
Launched

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