Merbromin

• Description :

  Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC50 of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye[1][2].

• Product Name Alternative :

  Mercury dibromofluorescein (disodium salt) ; ZP1

• UNSPSC :

  12171500

• Hazard Statement :

  H300, H310, H330, H373, H400, H410

• Target :

  Flavivirus; Proteasome

• Type :

  Dye Reagents

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Merbromin.html

• Solubility :

  DMSO : 6.67 mg/mL (ultrasonic)

• Smiles :

  O[Hg]C1=C(O[Na])C(Br)=CC(C2C3=C(C=CC=C3)C(O[Na])=O)=C1OC4=C2C=C(Br)C(O)=C4

• Molecular Formula :

  C20H10Br2HgNa2O6

• Molecular Weight :

  752.67

• Precautions :

  H300, H310, H330, H373, H400, H410

• References & Citations :

  [1]Xiangling Cui , et al. Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313.|[2]Junjie Chen, et al. Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2. Biochem Biophys Res Commun. 2022 Feb 5:591:118-123.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Dye Reagents

• Clinical Information :

  Launched

• CAS Number :

  [129-16-8]