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FANCD2 Polyclonal Antibody

CAT: 0749-ABP51326-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51326-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. FANCD2 encodes the protein for complementation group D2. Fanconi anemia group D2 protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.
Description
Rabbit Anti-FANCD2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
FANCD2; FACD; Fanconi anemia group D2 protein; Protein FACD2
Gene ID
2177
Accession Number
Q9BXW9
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human FANCD2 around the non-phosphorylation site of S222
Clonality
Polyclonal
Tag
Fanconi anemia group D2 protein
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
166kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
FANCD2 Polyclonal Antibody detects endogenous levels of FANCD2 protein.
Observed Molecular Weight
166
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
FANCD2; FACD; Fanconi anemia group D2 protein; Protein FACD2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9BXW9
Isotype
Rabbit IgG

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