DTMP Kinase Polyclonal Antibody

• Background :

  Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.

• Description :

  Rabbit Anti-dTMP Kinase Polyclonal Antibody

• Product Name Alternative :

  DTYMK; CDC8; TMPK; TYMK; Thymidylate kinase; dTMP kinase

• Gene ID :

  1841

• Accession Number :

  P23919

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthesized peptide derived from the N-terminal region of human dTMP Kinase at AA range: 1-80

• Clonality :

  Polyclonal

• Tag :

  Thymidylate kinase

• Applications :

  WB, IHC, IF, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  22kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  DTMP Kinase Polyclonal Antibody detects endogenous levels of dTMP Kinase protein.

• Observed Molecular Weight :

  22

• Formulation :

  Liquid solution

• Buffer pH :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200

• Other Product Names :

  DTYMK; CDC8; TMPK; TYMK; Thymidylate kinase; dTMP kinase

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/P23919

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG