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Cyclin H Polyclonal Antibody

CAT: 0749-ABP51087-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51087-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cyclin H encoded by CCNH belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK) . This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of CCNH is found on chromosome 4. Alternate splicing results in multiple transcript variants.
Description
Rabbit Anti-Cyclin H Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CCNH; Cyclin-H; MO15-associated protein; p34; p37
Gene ID
902
Accession Number
P51946
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Cyclin H around the non-phosphorylation site of T315
Clonality
Polyclonal
Tag
Cyclin-H
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
38kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Cyclin H Polyclonal Antibody detects endogenous levels of Cyclin H protein.
Observed Molecular Weight
38
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Other Product Names
CCNH; Cyclin-H; MO15-associated protein; p34; p37
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P51946
Isotype
Rabbit IgG

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