CD88 Polyclonal Antibody

• Background:

  CD88, also known as C5a receptor (C5aR), is a G protein-coupled integral membrane protein. CD88, which is expressed on neutrophils, monocytes, macrophages, hepatocytes and mast cells, as well as on various epithelial and endothelial cells, serves as a receptor for the inflammatory peptide C5a. Research studies suggest a role for CD88 in the inflammatory response. The binding of C5a to CD88 has been shown to elicit increased production of acute phase proteins in liver. In brain, an increased production of CD88 has been shown to be associated with inflammation. Research also indicates a role for C5a/C5aR in the pathogenesis of rheumatoid arthritis, as well as a heightened responsiveness of human bronchial epithelial cells (HBECs) to C5a upon exposure of these cells to cigarette smoke and other environmental irritants.

• Description:

  Rabbit Anti-CD88 Polyclonal Antibody

• Product Name Alternative:

  C5AR1; C5AR; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD antigen CD88

• Gene ID:

  728

• Accession Number:

  P21730

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Synthesized peptide derived from human CD88 around the non-phosphorylation site of S338

• Clonality:

  Polyclonal

• Tag:

  C5a anaphylatoxin chemotactic receptor

• Applications:

  WB, IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  45kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  CD88 Polyclonal Antibody detects endogenous levels of CD88 protein.

• Observed Molecular Weight:

  45

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.

• Other Product Names:

  C5AR1; C5AR; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD antigen CD88

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P21730

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG