CBP Polyclonal Antibody

CAT: 0749-ABP50880-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP50880-01Size:30 µL
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Background
CREBBP is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), CREBBP is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREB binding protein has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. CREB binding protein acetylates both histone and non-histone proteins. CREB binding protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in CREBBP cause Rubinstein-Taybi syndrome (RTS) . Chromosomal translocations involving CREBBP have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Description
Rabbit Anti-CBP Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CREBBP; CBP; CREB-binding protein
Gene ID
1387
Accession Number
Q92793
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human CBP around the non-acetylation site of K1535 at AA range: 1480-1550
Clonality
Polyclonal
Tag
CREB-binding protein
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
265kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
CBP Polyclonal Antibody detects endogenous levels of CBP protein.
Observed Molecular Weight
265
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Other Product Names
CREBBP; CBP; CREB-binding protein
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q92793
Isotype
Rabbit IgG

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