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Caspase 12 Polyclonal Antibody

CAT: 0749-ABP50853-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50853-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. CASP12 is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of CASP12 mediates apoptosis in response to endoplasmic reticulum stress. However, in humans CASP12 contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for CASP12.
Description
Rabbit Anti-Caspase12 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CASP12; Inactive caspase-12; CASP-12
Gene ID
120329
Accession Number
Q6UXS9
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Caspase12
Clonality
Polyclonal
Tag
Inactive caspase-12
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
50kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.
Observed Molecular Weight
50
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
CASP12; Inactive caspase-12; CASP-12
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q6UXS9
Isotype
Rabbit IgG

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