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CAS Polyclonal Antibody

CAT: 0749-ABP50845-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50845-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein (chromosome segregation 1 like) may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for CSE1L.
Description
Rabbit Anti-CAS Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
Gene ID
1434
Accession Number
P55060
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80
Clonality
Polyclonal
Tag
Exportin-2
Applications
WB, IHC, IP, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
110kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
CAS Polyclonal Antibody detects endogenous levels of CAS protein.
Observed Molecular Weight
110
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IP 2-5 ug:mg lysate; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P55060
Isotype
Rabbit IgG

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