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CARD 11 Polyclonal Antibody

CAT: 0749-ABP50841-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50841-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD) . This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
Description
Rabbit Anti-CARD 11 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CARD11; CARMA1; Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 1; Carma 1
Gene ID
84433
Accession Number
Q9BXL7
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of human CARD 11 at AA range: 10-90
Clonality
Polyclonal
Tag
Caspase recruitment domain-containing protein 11
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
130kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
CARD 11 Polyclonal Antibody detects endogenous levels of CARD 11 protein.
Observed Molecular Weight
130
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
CARD11; CARMA1; Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 1; Carma 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9BXL7
Isotype
Rabbit IgG

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