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Caspase-14 Polyclonal Antibody

CAT: 0749-ABP50016-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50016-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 14 has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of caspase 14 may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Description
Rabbit Anti-Caspase-14 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CASP14; Caspase-14; CASP-14
Gene ID
23581
Accession Number
P31944
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Caspase-14 at AA range: 110-190
Clonality
Polyclonal
Tag
Caspase-14
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
27kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Caspase-14 Polyclonal Antibody detects endogenous levels of Caspase-14 protein.
Observed Molecular Weight
27
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
CASP14; Caspase-14; CASP-14
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P31944
Isotype
Rabbit IgG

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