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DMNQ

CAT: 0804-HY-121026-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-121026-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production[1][2].
CAS Number
[6956-96-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Reactive Oxygen Species (ROS) ; ROS Kinase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dmnq.html
Purity
99.8
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(OC)=C(C(C2=CC=CC=C21)=O)OC
Molecular Formula
C12H10O4
Molecular Weight
218.21
Precautions
H315, H319, H335
References & Citations
[1]Watanabe N, et al. Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells. Arch Biochem Biophys. 2003 Mar 1;411 (1) :145-57.|[2]Shi MM, et al. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. J Biol Chem. 1994 Oct 21;269 (42) :26512-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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