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MYOC rabbit pAb

CAT: 0855-ES10926-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10926-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR) . The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]
Description
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008],
UniProt
Q99972
Swiss Prot
Q99972
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
MYOC
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
55kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
55kD
Fragment
IgG
Subcellular Location
Secreted . Golgi apparatus . Cytoplasmic vesicle . Secreted, extracellular space. Secreted, extracellular space, extracellular matrix . Secreted, extracellular exosome . Mitochondrion . Mitochondrion intermembrane space . Mitochondrion inner membrane . Mitochondrion outer membrane . Rough endoplasmic reticulum . Cell projection. Cell projection, cilium . Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum (PubMed:9169133) . It is only imported to mitochondria in the trabecular meshwork (PubMed:17516541) . Localizes to the Golgi apparatus in Schlemm's canal endothelial cells (PubMed:11053284) . Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely as
Gene ID (Human)
4653

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