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α-Zearalenol

CAT: 0804-HY-N6710-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6710-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects[1].
CAS Number
36455-72-8
UNSPSC
12352005
Hazard Statement
H302, H314, H351, H361, H371, H412
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alpha-zearalenol.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C2C(O[C@H](CCC[C@@H](CCC/C=C/C2=CC(O)=C1)O)C)=O
Molecular Formula
C18H24O5
Molecular Weight
320.38
Precautions
H302, H314, H351, H361, H371, H412
References & Citations
[1].Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28 (4) :239-242.|[2]Marin DE, et al. Cytotoxic and inflammatory effects of individual and combined exposure of HepG2 cells to zearalenone and its metabolites. Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392 (8) :937-947.|[3]Nittoli AC, et al. Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach. Metabolomics. 2018 Feb 14;14 (3) :33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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