IL18 rabbit pAb

• Background :

  The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

• Description :

  The protein encoded by this gene is a proinflammatory Cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

• UniProt :

  Q14116

• Swiss Prot :

  Q14116

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  IL18

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  21kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  21kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744) . In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744) . Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744) . In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744) . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059) . .

• Gene ID (Human) :

  3606