RIPK1 rabbit pAb
CAT:
855-ES10796-02
Size:
100 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
RIPK1 rabbit pAb
- Description: Catalytic activity: ATP + a protein = ADP + a phosphoprotein. function: Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B. PTM: Autophosphorylated on serine and threonine residues. PTM: Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction. similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. similarity: Contains 1 death domain. similarity: Contains 1 protein kinase domain. subunit: Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1.
- Gene ID: 8737
- UniProt: Q13546
- Cellular Locus: Cytoplasm. Cell membrane.
- Host: Rabbit
- Species Reactivity: Human, Rat, Mouse,
- Immunogen: Synthesized peptide derived from part region of human protein
- Clonality: Polyclonal
- Validated Applications: WB, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: WB 1:500-2000 ELISA 1:5000-20000
- Molecular Weight: 73kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.