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PTPRD rabbit pAb

CAT: 0855-ES10140-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10140-02Size:100 µL
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010],
UniProt
P23468
Swiss Prot
P23468
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 510-590
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
210kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
210kD
Fragment
IgG
Subcellular Location
Membrane; Single-pass type I membrane protein.
Gene ID (Human)
5789

UniProtKB · P23468

Receptor-type tyrosine-protein phosphatase delta

PTPRD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23468
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPRD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein-tyrosine phosphatase delta, R-PTP-delta
EC number
3.1.3.48
Processing
Precursor
Secondary accessions
B1ALA0, F5GWT7, Q3KPJ0, Q3KPJ1, Q3KPJ2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoprotein

Molecular function

HydrolaseProtein phosphataseReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

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