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PTPRB rabbit pAb

CAT: 0855-ES10139-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10139-01Size:50 µL
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite gro
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite gro
UniProt
P23467
Swiss Prot
P23467
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 280-360
Target
PTPRB
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
219kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
219kD
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type I membrane protein .
Gene ID (Human)
5787

UniProtKB · P23467

Receptor-type tyrosine-protein phosphatase beta

PTPRB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23467
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPRB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Protein-tyrosine phosphatase beta, R-PTP-beta
EC number
3.1.3.48
Processing
Precursor
Secondary accessions
B7ZKS8, B7ZKT0, C9JX87, F5H3G6, Q14D85, Q3MIV7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Angiogenesis

PTM

GlycoproteinPhosphoprotein

Molecular function

HydrolaseProtein phosphatase

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

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