RAB21 rabbit pAb

CAT: 0855-ES10116-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES10116-01Size:50 µL
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Background
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]
Description
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015],
UniProt
Q9UL25
Swiss Prot
Q9UL25
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 60-140
Target
RAB21
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
24kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
24kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Lipid-anchor . Golgi apparatus, trans-Golgi network . Golgi apparatus membrane . Early endosome membrane . Cytoplasmic vesicle membrane . Cleavage furrow . Cell projection, neuron projection . Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity) . In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961) . During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435) . In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435) . .
Gene ID (Human)
23011

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