EGF rabbit pAb

• Background:

  This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

• Description:

  This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],

• UniProt:

  P01133

• Swiss Prot:

  P01133

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthetic peptide from human protein at AA range: 1000-1060

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000, IHC-p 1:500-200, ELISA 1:10000-20000

• Molecular Weight:

  130kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  130kD

• Fragment:

  IgG

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Other Product Names:

  Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone) ]

• Gene ID (Human):

  1950