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Flt-4 rabbit pAb

CAT: 0855-ES8649-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8649-01Size:50 µL
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Background
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Description
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008],
UniProt
P35916
Swiss Prot
P35916
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide from human protein at AA range: 640-700
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, IHC-p 1:500-200, ELISA 1:10000-20000
Molecular Weight
170kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
170kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein. Cytoplasm . Nucleus . Ligand-mediated autophosphorylation leads to rapid internalization. .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Ligand-mediated autophosphorylation leads to rapid internalization.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Cytoplasm.
Other Product Names
Vascular endothelial growth factor receptor 3 (VEGFR-3; EC 2.7.10.1; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4)
Gene ID (Human)
2324

UniProtKB · P35916

Vascular endothelial growth factor receptor 3

VGFR3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35916
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLT4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
VEGFR-3
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A8K6L4, B5A926, Q16067, Q86W07, Q86W08
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Angiogenesis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembraneNucleusSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

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