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Collagen IV rabbit pAb

CAT: 0855-ES8486-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8486-01Size:50 µL
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Background
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Description
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Product Name Alternative
Collagen, type IV, alpha 1
UniProt
P02462
Swiss Prot
P02462
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from Collagen IV . at AA range: 1428-1443
Target
Collagen IV
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130kD
Fragment
IgG
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane .
Other Product Names
Collagen, type IV, alpha 1
Gene ID (Human)
1282

UniProtKB · P02462

Collagen alpha-1(IV) chain

CO4A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02462
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
COL4A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A7E2W4, B1AM70, F5H5K0, Q1P9S9, Q5VWF6, Q86X41, Q8NF88, Q9NYC5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Angiogenesis

Cellular component

Basement membraneExtracellular matrixSecreted

Domain

CollagenRepeatSignal

Disease

Disease variant

PTM

Disulfide bondGlycoproteinHydroxylation

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