p300 (Acetyl Lys1558/Acetyl Lys1560) rabbit pAb

p300 (Acetyl Lys1558/Acetyl Lys1560) rabbit pAb

• Description: E1A binding protein p300 (EP300) Homo sapiens This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008],
• Synonyms: EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300
• Gene ID: 2033
• UniProt: Q09472
• Cellular Locus: Cytoplasm. Nucleus. Chromosome. Localizes to active chromatin: Colocalizes with histone H3 acetylated and/or crotonylated at 'Lys-18' (H3K18ac and H3K18cr, respectively) (PubMed:25818647). In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Colocalizes with ROCK2 in the nucleus (PubMed:12929931)..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized acetyl-peptide derived from human p300 around the acetylation site of K1558.
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
• Molecular Weight: 300kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.