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MELK rabbit pAb

CAT: 0855-ES8105-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8105-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis., PTM:Autophosphorylated. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily., similarity:Contains 1 KA1 (kinase-associated) domain., similarity:Contains 1 protein kinase domain., subunit:Interacts with ZNF622 and PPP1R8., tissue specificity:Expressed in placenta, kidney, thymus, testis, ovary and intestine.
Description
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. function: Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis. PTM: Autophosphorylated. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8. similarity: Belongs to the protein kinase superfamily. similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. similarity: Contains 1 KA1 (kinase-associated) domain. similarity: Contains 1 protein kinase domain. subunit: Interacts with ZNF622 and PPP1R8. tissue specificity: Expressed in placenta, kidney, thymus, testis, ovary and intestine.
UniProt
Q14680
Swiss Prot
Q14680
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MELK. AA range:431-480
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
75kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
75kD
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein .
Other Product Names
MELK; KIAA0175; Maternal embryonic leucine zipper kinase; hMELK; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK
Gene ID (Human)
9833

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