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TMEM185A rabbit pAb

CAT: 0855-ES7761-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7761-02Size:100 µL
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Background
The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]
Description
The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013],
Product Name Alternative
TMEM185A; CXorf13; FAM11A; Transmembrane protein 185A; Protein FAM11A
UniProt
Q8NFB2
Swiss Prot
Q8NFB2
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TMEM185A. AA range:290-339
Target
TMEM185A
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
41kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
41kD
Fragment
IgG
Subcellular Location
Cell projection, dendrite . Membrane ; Multi-pass membrane protein .
Other Product Names
TMEM185A; CXorf13; FAM11A; Transmembrane protein 185A; Protein FAM11A
Gene ID (Human)
84548

UniProtKB · Q8NFB2

Transmembrane protein 185A

T185A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NFB2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TMEM185A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B3KTZ3, Q3SYH1, Q96CW3, Q96KE8
Protein keywords

Cellular component

Cell projectionMembrane

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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