CD88 (phospho Ser338) rabbit pAb

CAT: 0855-ES7460-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES7460-01Size:50 µL

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Background

Function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production., PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist., similarity:Belongs to the G-protein coupled receptor 1 family.

Description

Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. PTM: Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. similarity: Belongs to the G-protein coupled receptor 1 family.

UniProt

P21730

Swiss Prot

P21730

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human CD88/C5aR around the phosphorylation site of Ser338. AA range:301-350

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle . Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. .

Other Product Names

C5AR1; C5AR; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD antigen CD88

Gene ID (Human)

728

UniProtKB · P21730

C5a anaphylatoxin chemotactic receptor 1

C5AR1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P21730
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: C5AR1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: —

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneCytoplasmic vesicleMembrane

Biological process

Chemotaxis

PTM

Disulfide bondGlycoproteinPhosphoproteinSulfation

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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Alternative Products

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