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Topo IIβ rabbit pAb

CAT: 0855-ES7419-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7419-01Size:50 µL
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Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
Description
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
UniProt
Q02880
Swiss Prot
Q02880
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TOP2B. AA range:1-50
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
183kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
183kD
Fragment
IgG
Subcellular Location
Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus .
Other Product Names
TOP2B; DNA topoisomerase 2-beta; DNA topoisomerase II; beta isozyme
Gene ID (Human)
7155

UniProtKB · Q02880

DNA topoisomerase 2-beta

TOP2B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q02880
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TOP2B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
5.6.2.2
Processing
—
Secondary accessions
Q13600, Q9UMG8, Q9UQP8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Disease

Autism spectrum disorderDisease variant

Molecular function

DNA-bindingIsomeraseTopoisomerase

Cellular component

Nucleus

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