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Thymidine Kinase rabbit pAb

CAT: 0855-ES7398-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7398-01Size:50 µL
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Background
Catalytic activity:ATP + thymidine = ADP + thymidine 5'-phosphate., miscellaneous:Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells., PTM:Phosphorylated on Ser-13 in mitosis., similarity:Belongs to the thymidine kinase family.
Description
Catalytic activity: ATP + thymidine = ADP + thymidine 5'-phosphate. miscellaneous: Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells. PTM: Phosphorylated on Ser-13 in mitosis. similarity: Belongs to the thymidine kinase family.
Product Name Alternative
TK1; Thymidine kinase; cytosolic
UniProt
P04183
Swiss Prot
P04183
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human TK. AA range:1-50
Target
Thymidine Kinase
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
25kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
25kD
Fragment
IgG
Subcellular Location
Cytoplasm.
Other Product Names
TK1; Thymidine kinase; cytosolic
Gene ID (Human)
7083

UniProtKB · P04183

Thymidine kinase, cytosolic

KITH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04183
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.1.21
Processing
—
Secondary accessions
B2RC58, Q969V0, Q9UMG9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Cellular component

Cytoplasm

Biological process

DNA synthesis

Molecular function

KinaseTransferase

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