Products for Research Use Only
RegisterLogin

Stat2 (phospho Tyr631) rabbit pAb

CAT: 0855-ES7295-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES7295-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
UniProt
P52630
Swiss Prot
P52630
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr631. AA range:597-646
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .
Other Product Names
STAT2; Signal transducer and activator of transcription 2; p113
Gene ID (Human)
6773

UniProtKB · P52630

Signal transducer and activator of transcription 2

STAT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52630
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
STAT2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DLC7, G3V2M6, Q16430, Q16431, Q9UDL4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variant

PTM

PhosphoproteinUbl conjugation

Domain

SH2 domain

Related Products

CatalogName
ES1478-01Stat2 (phospho Tyr690) rabbit pAb
EA207-01STAT2 Rabbit pAb
ES3510-01Stat2 rabbit pAb
ES1409-01Stat6 (phospho Tyr641) rabbit pAb
ES20131-01Stat2 (Acetyl Lys384) rabbit pAb
ES6770-01Axl (phospho Tyr691) rabbit pAb
ES5971-01JAK2 (phospho Tyr931) rabbit pAb
ES8016-01CD19 (phospho Tyr531) rabbit pAb
ES7505-01Vimentin (phospho Tyr61) rabbit pAb
ES1393-01Paxillin (phospho Tyr31) rabbit pAb

Alternative Products

CatalogName
OASG06859-100ULSTAT2 Antibody (Phospho-Tyr631)
AF8127-BPPhospho-STAT2 (Tyr631) Peptide
A8063-01Stat2 (phospho Tyr631) Antibody
E11-8063ASTAT2 (Phospho-Tyr631) Antibody
MBS9614128-01Phospho-STAT2 (Tyr631) Antibody
ABF8127STAT2 (Phospho-Tyr631) Antibody
E28PP1034Stat2 (phospho Tyr631) Rabbit Polyclonal Antibody
BT-AP14530-01Stat2 (Phospho Tyr631) Polyclonal Antibody
MBS9619090-01Phospho-STAT2 (Tyr631) Blocking Peptide
JOT-AP14530-01Stat2(Phospho Tyr631) Polyclonal Antibody

Popular Products