BRCA1 rabbit pAb

CAT: 0855-ES7271-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0855-ES7271-02Size:100 µL

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Background

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC) . This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian

Description

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian

UniProt

P38398

Swiss Prot

P38398

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human BRCA1. AA range:955-1004

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus . Chromosome . Cytoplasm . Localizes at sites of DNA damage at double-strand breaks (DSBs) ; recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126) . Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719) . .; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm .

Other Product Names

BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53

Gene ID (Human)

672

UniProtKB · P38398

Breast cancer type 1 susceptibility protein

BRCA1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P38398
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BRCA1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.3.2.27
Processing: —
Secondary accessions: E9PFZ0, O15129, Q1RMC1, Q3LRJ0, Q3LRJ6, Q6IN79, Q7KYU9

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingTransferase

Coding sequence diversity

Alternative initiationAlternative splicing

Biological process

Cell cycleDNA damageDNA recombinationDNA repairTranscriptionTranscription regulationUbl conjugation pathway

Cellular component

ChromosomeCytoplasmNucleus

Disease

Disease variantFanconi anemiaTumor suppressor

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

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Catalog	Name
APA4187-01	BRCA1 Rabbit pAb
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