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RGS12 rabbit pAb

CAT: 0855-ES7043-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase) -activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Description
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008],
Product Name Alternative
RGS12; Regulator of G-protein signaling 12; RGS12
UniProt
O14924
Swiss Prot
O14924
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human RGS12. AA range:141-190
Target
RGS12
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
160kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
160kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Cell projection, dendrite . Cell junction, synapse .; [Isoform 5]: Nucleus matrix . Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. .
Other Product Names
RGS12; Regulator of G-protein signaling 12; RGS12
Gene ID (Human)
6002

UniProtKB · O14924

Regulator of G protein signaling 12

RGS12_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14924
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RGS12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
RGS12
EC number
—
Processing
—
Secondary accessions
B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O43510, O75338, Q147X0, Q8WX95
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionCytoplasmNucleusSynapse

Molecular function

GTPase activationRepressorSignal transduction inhibitor

PTM

Isopeptide bondMethylationPhosphoproteinUbl conjugation

Domain

Repeat

Biological process

Transcription