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NFκB-p65 rabbit pAb

CAT: 0855-ES7026-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7026-01Size:50 µL
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Background
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Description
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
UniProt
Q04206
Swiss Prot
Q04206
Reactivity
Human; Mouse; Rat; pig
Immunogen
The antiserum was produced against synthesized peptide derived from human NF-kappaB p65. AA range:247-296
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333) . Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135) . Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752) . Translocation to the nucleus is impaired in L.monocytogenes infection (PubMed:20855622) . .
Other Product Names
RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene ID (Human)
5970

UniProtKB · Q04206

Transcription factor p65

TF65_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04206
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RELA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6GTV1, Q6SLK1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

CytoplasmNucleus

Disease

Disease variant

Biological process

Host-virus interactionTranscriptionTranscription regulation

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