Bcl-2 (phospho Thr74) rabbit pAb

• Background:

  BCL2, apoptosis regulator (BCL2) Homo sapiens This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

• Description:

  BCL2, apoptosis regulator (BCL2) Homo sapiens This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

• Synonyms:

  BCL2; Apoptosis regulator Bcl-2

• Gene ID:

  596

• UniProt:

  P10415

• Cellular Locus:

  Mitochondrion outer membrane ; Single-pass membrane protein. Nucleus membrane ; Single-pass membrane protein. Endoplasmic reticulum membrane ; Single-pass membrane protein. Cytoplasm.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized phospho-peptide around the phosphorylation site of human Bcl-2 (phospho Thr74)

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  IHC, IF, ELISA

• Validated Applications:

  IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Subcellular Location:

  Mitochondrion outer membrane ; Single-pass membrane protein . Nucleus membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Cytoplasm .

• Other Product Names:

  BCL2; Apoptosis regulator Bcl-2

• Gene ID (Human):

  596

• SwissProt (Human):

  P10415