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Formin 2 rabbit pAb

CAT: 0855-ES6855-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6855-01Size:50 µL
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Background
This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47) . Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Description
This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015],
UniProt
Q9NZ56
Swiss Prot
Q9NZ56
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human FMN2. AA range:1541-1590
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton . Cytoplasm, cytosol . Cytoplasm, perinuclear region . Nucleus . Nucleus, nucleolus . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cell cortex . Colocalizes with the actin cytoskeleton (PubMed:20082305) . Recruited to the membranes via its interaction with SPIRE1 (By similarity) . Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity) . Accumulates in the nucleus following DNA damage (PubMed:26287480) . .
Other Product Names
FMN2; Formin-2
Gene ID (Human)
56776

UniProtKB · Q9NZ56

Formin-2

FMN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NZ56
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FMN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B0QZA7, B4DP05, Q59GF6, Q5VU37, Q9NZ55
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-bindingDevelopmental protein

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmCytoplasmic vesicleCytoskeletonMembraneNucleus

Domain

Coiled coil

Biological process

DNA damageProtein transportStress responseTransport

Disease

Intellectual disability

PTM

Phosphoprotein

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