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PS-1 rabbit pAb

CAT: 0855-ES6848-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6848-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Description
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008],
UniProt
P49768
Swiss Prot
P49768
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Presenilin 1. AA range:1-50
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:100-500; IF/ICC 1:100-500; ELISA 1:5000-20000
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic granule . Cell membrane ; Multi-pass membrane protein . Cell projection, growth cone . Early endosome . Early endosome membrane ; Multi-pass membrane protein . Cell projection, neuron projection . Cell projection, axon . Cell junction, synapse . Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface (PubMed:10593990) . Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane (PubMed:9738936) . Also present in azurophil granules of neutrophils (PubMed:11987239) . Colocalizes with UBQLN1 in the cell membrane and
Other Product Names
PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182
Gene ID (Human)
5663

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Alternative Products

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GTR17694871Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody
GTR18768227Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (Fluoro647)
GTR18545870Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (Biotin)
GTR18545867Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (FITC)
GTR18545864Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (PE)
GTR18545869Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (Cy3)
GTR18545865Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (APC)
GTR18768228Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (Fluoro594)
GTR18768230Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (Fluoro488)
GTR18768229Presenilin 1/PS-1/PSEN1/PS Rabbit Polyclonal Antibody (Fluoro550)

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