Pim-1 (phospho Tyr309) rabbit pAb
CAT:
855-ES6588-02
Size:
100 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Pim-1 (phospho Tyr309) rabbit pAb
- Description: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs: 16186805, 1825810). [provided by RefSeq, Aug 2011],
- Synonyms: PIM1; Serine/threonine-protein kinase pim-1
- Gene ID: 5292
- UniProt: P11309
- Cellular Locus: [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: The antiserum was produced against synthesized peptide derived from human Pim-1 around the phosphorylation site of Tyr309. AA range:281-330
- Clonality: Polyclonal
- Validated Applications: WB, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
- Molecular Weight: 45kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.