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Myosin IXb rabbit pAb

CAT: 0855-ES6320-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6320-01Size:50 µL
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Background
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9) . The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Description
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
UniProt
Q13459
Swiss Prot
Q13459
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MYO9B. AA range:304-353
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Molecular Weight
250kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
250kD
Fragment
IgG
Subcellular Location
Cytoplasm, cell cortex . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. .
Other Product Names
MYO9B; MYR5; Unconventional myosin-IXb; Unconventional myosin-9b
Gene ID (Human)
4650

UniProtKB · Q13459

Unconventional myosin-IXb

MYO9B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13459
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYO9B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O75314, Q9NUJ2, Q9UHN0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Actin-bindingCalmodulin-bindingGTPase activationMotor proteinMyosin

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Domain

Coiled coilRepeatZinc-finger

Cellular component

CytoplasmCytoskeleton

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