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Mcl-1 (phospho Ser159) rabbit pAb

CAT: 0855-ES6205-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Description
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010],
Product Name Alternative
MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
UniProt
Q07820
Swiss Prot
Q07820
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MCL1 around the phosphorylation site of Ser159. AA range:125-174
Target
Mcl-1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
About 40kd in human,39kd in mouse and rat
Storage Conditions
-20°C/1 year
Observed Molecular Weight
About 40kd in human,39kd in mouse and rat
Fragment
IgG
Subcellular Location
Membrane ; Single-pass membrane protein . Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Cytoplasmic, associated with mitochondria.
Other Product Names
MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
Gene ID (Human)
4170

UniProtKB · Q07820

Induced myeloid leukemia cell differentiation protein Mcl-1

MCL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q07820
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MCL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R6B2, D3DV03, D3DV04, Q9HD91, Q9NRQ3, Q9NRQ4, Q9UHR7, Q9UHR8, Q9UHR9, Q9UNJ1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisDifferentiation

Cellular component

CytoplasmMembraneMitochondrionNucleus

Molecular function

Developmental protein

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

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