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Arginase I rabbit pAb

CAT: 0855-ES6028-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Description
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
Product Name Alternative
ARG1; Arginase-1; Liver-type arginase; Type I arginase
UniProt
P05089
Swiss Prot
P05089
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ARG1. AA range:61-110
Target
Arginase I
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
35kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
35kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasmic granule . Localized in azurophil granules of neutrophils (PubMed:15546957) . .
Other Product Names
ARG1; Arginase-1; Liver-type arginase; Type I arginase
Gene ID (Human)
383

UniProtKB · P05089

Arginase-1

ARGI1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05089
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ARG1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.5.3.1
Processing
—
Secondary accessions
A6NEA0, Q5JWT5, Q5JWT6, Q8TE72, Q9BS50
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityArginine metabolismImmunityInnate immunityUrea cycle

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Disease

Disease variant

Molecular function

Hydrolase

Ligand

ManganeseMetal-binding

PTM

Phosphoprotein

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