GFRα-1 rabbit pAb

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Background

This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Description

This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],

UniProt

P56159

Swiss Prot

P56159

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human GFR alpha-1. AA range:51-100

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cell membrane ; Lipid-anchor, GPI-anchor . Golgi apparatus, trans-Golgi network . Endosome . Endosome, multivesicular body . Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. .

Other Product Names

GFRA1; GDNFRA; RETL1; TRNR1; GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1

Gene ID (Human)

2674

UniProtKB · P56159

GDNF family receptor alpha-1

GFRA1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P56159
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GFRA1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1
EC number: —
Processing: Precursor
Secondary accessions: A8KA21, O15507, O43912

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeGolgi apparatusMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinGPI-anchorLipoprotein

Molecular function

Receptor

Domain

RepeatSignal

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