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CD32 rabbit pAb

CAT: 0855-ES5228-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5228-02Size:100 µL
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Background
The Fc fragment of IgG receptor IIb encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE) . Several transcript variants encoding different isoforms have been found for this gene.
Description
The Fc fragment of IgG receptor IIb encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
UniProt
P31994
Swiss Prot
P31994
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CD32. AA range:277-326
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
34kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
34kD
Fragment
IgG
Gene ID (Human)
2213

UniProtKB · P31994

Low affinity immunoglobulin gamma Fc region receptor II-b

FCG2B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31994
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FCGR2B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IgG Fc receptor II-b
EC number
—
Processing
Precursor
Secondary accessions
A6H8N3, O95649, Q53X85, Q5VXA9, Q8NIA1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Host-virus interaction

Molecular function

IgG-binding proteinReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Disease

Proto-oncogeneSystemic lupus erythematosus

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