EpoR (phospho Tyr368) rabbit pAb

CAT: 0855-ES5137-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES5137-01Size:50 µL

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Background

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Description

This gene encodes the erythropoietin receptor which is a member of the Cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010],

Product Name Alternative

EPOR; Erythropoietin receptor; EPO-R

UniProt

P19235

Swiss Prot

P19235

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Epo-R around the phosphorylation site of Tyr368. AA range:341-390

Target

EpoR

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

55kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

55kD

Fragment

IgG

Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted . Secreted and located to the cell surface.

Other Product Names

EPOR; Erythropoietin receptor; EPO-R

Gene ID (Human)

2057

UniProtKB · P19235

Erythropoietin receptor

EPOR_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P19235
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EPOR
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: EPO-R
EC number: —
Processing: Precursor
Secondary accessions: B2RCG4, Q15443, Q2M205

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

Disease

Congenital erythrocytosisDisease variant

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix

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Alternative Products

Catalog	Name
OAAJ02500-100UL	EPOR Antibody (Phospho-Tyr368)
CSB-PA598485	Phospho-EPOR (Tyr368) Antibody
A0917-01	EpoR (phospho Tyr368) Antibody
E53P01742	EpoR phospho-Tyr368 Rabbit Polyclonal Antibody
GTR18051840-01	EpoR (phospho Tyr368) rabbit pAb Antibody
E28PP0552	EpoR (phospho Tyr368) Rabbit Polyclonal Antibody
MBS8520326-01	EpoR (phospho Tyr368) Polyclonal Antibody
JOT-AP08926-01	EpoR(Phospho Tyr368) Polyclonal Antibody
TMAC-01343-01	Anti-Phospho-EPOR (Tyr368) Polyclonal Antibody
E53P03798	EpoR Tyr368 Rabbit Polyclonal Antibody