Products for Research Use Only
RegisterLogin

EGFR (phospho Tyr1069) rabbit pAb

CAT: 0855-ES5056-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES5056-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],
Product Name Alternative
EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
UniProt
P00533
Swiss Prot
P00533
Reactivity
Human; Mouse; Rat; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human EGFR around the phosphorylation site of Tyr1069. AA range:1041-1090
Target
EGFR
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
175kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
175kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029) . Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029) . Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055) . .; [Isoform 2]: Secreted.
Other Product Names
EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
Gene ID (Human)
1956

UniProtKB · P00533

Epidermal growth factor receptor

EGFR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00533
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EGFR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneEndoplasmic reticulumEndosomeGolgi apparatusMembraneNucleusSecreted

Molecular function

Developmental proteinHost cell receptor for virus entryKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variantProto-oncogene

PTM

Disulfide bondGlycoproteinHydroxylationIsopeptide bondLipoproteinMethylationPalmitatePhosphoproteinUbl conjugation

Biological process

Host-virus interaction

Domain

RepeatSignalTransmembraneTransmembrane helix

Related Products

CatalogName
ES5060-01EGFR (phospho Tyr1016) rabbit pAb
ES1301-01EGFR (phospho Tyr1092) rabbit pAb
ES16782-01EGFR (Phospho-Tyr998) rabbit pAb
ES1300-01EGFR (phospho Thr693) rabbit pAb
ES1302-01EGFR (phospho Tyr1110) rabbit pAb
ES5059-01EGFR (phospho Ser1071) rabbit pAb
ES5054-01EGFR (phospho Tyr1172) rabbit pAb
ES1303-01EGFR (phospho Tyr1197) rabbit pAb
ES5053-01EGFR (phospho Ser1070) rabbit pAb
ES1447-01EGFR (phospho Thr678) rabbit pAb

Alternative Products

CatalogName
MBS9502746-01EGFR (Phospho-Tyr1069) Antibody
MBS8541732-01EGFR (Phospho-Tyr1069) Rabbit pAb
A0912-01EGFR (phospho Tyr1069) Antibody
ABP54057-01EGFR (phospho Tyr1069) Polyclonal Antibody
APRab04591-01EGFR (phospho Tyr1069) Rabbit Polyclonal Antibody
GTR18051804-01EGFR (phospho Tyr1069) rabbit pAb Antibody
E53P01675EGFR phospho-Tyr1069 Rabbit Polyclonal Antibody
MBS9413170-01EGFR (Phospho-Tyr1069) Polyclonal Antibody
EKA51292Phospho-EGFR (Tyr1069) ELISA Kit
JOT-AP08758-01EGFR(Phospho Tyr1069) Polyclonal Antibody

Popular Products