Dvl-2 rabbit pAb
CAT:
855-ES5034-01
Size:
50 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Dvl-2 rabbit pAb
- Description: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008],
- Synonyms: DVL2; Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2
- Gene ID: 1856
- UniProt: O14641
- Cellular Locus: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Nucleus. Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136)..
- Host: Rabbit
- Species Reactivity: Human, Mouse
- Immunogen: Synthesized peptide derived from Dvl-2 . at AA range: 670-750
- Clonality: Polyclonal
- Validated Applications: WB, IHC, IF, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Molecular Weight: 80kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.